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small molecule chir99021  (Tocris)


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    Tocris small molecule chir99021
    Small Molecule Chir99021, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/small molecule chir99021/product/Tocris
    Average 90 stars, based on 1 article reviews
    small molecule chir99021 - by Bioz Stars, 2026-04
    90/100 stars

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    ( A ) Representative IHC staining of apical DPEP1 at the base of human normal colonic crypts. Scale bar: 100 μm. ( B ) Relative quantification for AXIN2 , NKD1 , and DPEP1 mRNA levels in normal colonic organoids with or without <t>CHIR99021</t> <t>(CHIR)</t> treatment ( n = 4 biological replicates). Error bars represent SEM. ( C – F ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to ( C ) APC ( n = 274), ( D ) P53 ( n = 356), ( E ) BRAF V600E ( n = 344) mutational status, and ( F ) MSI-H status ( n = 375). ( G ) Percentage of CRC samples from TMAs based on DPEP1 staining intensity as delineated by MSI status ( n = 105). ( H ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to CRC CMS categories ( n = 485). Median denoted in red. WT, wild-type; MUT, mutated; NS, no significance. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001 by Wilcoxon-Mann-Whitney, χ 2 ( B - F ), chi squared ( G ), and Kruskal-Wallis test ( H ).
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    ( A ) Representative IHC staining of apical DPEP1 at the base of human normal colonic crypts. Scale bar: 100 μm. ( B ) Relative quantification for AXIN2 , NKD1 , and DPEP1 mRNA levels in normal colonic organoids with or without <t>CHIR99021</t> <t>(CHIR)</t> treatment ( n = 4 biological replicates). Error bars represent SEM. ( C – F ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to ( C ) APC ( n = 274), ( D ) P53 ( n = 356), ( E ) BRAF V600E ( n = 344) mutational status, and ( F ) MSI-H status ( n = 375). ( G ) Percentage of CRC samples from TMAs based on DPEP1 staining intensity as delineated by MSI status ( n = 105). ( H ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to CRC CMS categories ( n = 485). Median denoted in red. WT, wild-type; MUT, mutated; NS, no significance. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001 by Wilcoxon-Mann-Whitney, χ 2 ( B - F ), chi squared ( G ), and Kruskal-Wallis test ( H ).
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    Image Search Results


    ( A ) Representative IHC staining of apical DPEP1 at the base of human normal colonic crypts. Scale bar: 100 μm. ( B ) Relative quantification for AXIN2 , NKD1 , and DPEP1 mRNA levels in normal colonic organoids with or without CHIR99021 (CHIR) treatment ( n = 4 biological replicates). Error bars represent SEM. ( C – F ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to ( C ) APC ( n = 274), ( D ) P53 ( n = 356), ( E ) BRAF V600E ( n = 344) mutational status, and ( F ) MSI-H status ( n = 375). ( G ) Percentage of CRC samples from TMAs based on DPEP1 staining intensity as delineated by MSI status ( n = 105). ( H ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to CRC CMS categories ( n = 485). Median denoted in red. WT, wild-type; MUT, mutated; NS, no significance. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001 by Wilcoxon-Mann-Whitney, χ 2 ( B - F ), chi squared ( G ), and Kruskal-Wallis test ( H ).

    Journal: JCI Insight

    Article Title: Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer

    doi: 10.1172/jci.insight.186938

    Figure Lengend Snippet: ( A ) Representative IHC staining of apical DPEP1 at the base of human normal colonic crypts. Scale bar: 100 μm. ( B ) Relative quantification for AXIN2 , NKD1 , and DPEP1 mRNA levels in normal colonic organoids with or without CHIR99021 (CHIR) treatment ( n = 4 biological replicates). Error bars represent SEM. ( C – F ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to ( C ) APC ( n = 274), ( D ) P53 ( n = 356), ( E ) BRAF V600E ( n = 344) mutational status, and ( F ) MSI-H status ( n = 375). ( G ) Percentage of CRC samples from TMAs based on DPEP1 staining intensity as delineated by MSI status ( n = 105). ( H ) DPEP1 mRNA expression of TCGA database COAD and READ cohorts as it relates to CRC CMS categories ( n = 485). Median denoted in red. WT, wild-type; MUT, mutated; NS, no significance. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001 by Wilcoxon-Mann-Whitney, χ 2 ( B - F ), chi squared ( G ), and Kruskal-Wallis test ( H ).

    Article Snippet: For experimental wells, the GSK3β small molecule inhibitor, CHIR99021 (Tocris, 4423), diluted in DMSO (Thermo Fisher Scientific) was added to the medium at a final concentration of 10 μM for 16 hours.

    Techniques: Immunohistochemistry, Quantitative Proteomics, Expressing, Staining, MANN-WHITNEY